Abstract
A series of bicyclic heteroaryl ring systems was considered as a replacement for the 3-cyclopentyloxy-4-methoxyphenyl moiety in rolipram resulting in the discovery of 8-methoxyquinoline-5-carboxamides as potent inhibitors of phosphodiesterase type 4 (PDE4).
MeSH terms
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3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
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Amides / pharmacology
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Amides / therapeutic use*
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Anti-Asthmatic Agents / pharmacology
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Anti-Asthmatic Agents / therapeutic use*
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Asthma / drug therapy*
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Cyclic Nucleotide Phosphodiesterases, Type 4
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Humans
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Phosphodiesterase Inhibitors / pharmacology
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Phosphodiesterase Inhibitors / therapeutic use*
Substances
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Amides
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Anti-Asthmatic Agents
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Phosphodiesterase Inhibitors
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3',5'-Cyclic-AMP Phosphodiesterases
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Cyclic Nucleotide Phosphodiesterases, Type 4